Isabella Leong joined in Emperor Entertainment Group at 12 years old , starting her work as a teenager model. First, she's taken part in singing. Her album debut (Isabella) was released when she was 16 years old. Though being supported a lot but her singing work didn't get such a big success so later, she switched to acting.
Actually beginning her film career with Bug me not ( after Sunshine Heartbeat series TV casting as guest).This film gave her a nomination for Best New Performer in Hong Kong Film Awards.
Cinematically, Leong's striking and delicately beautiful appearance put her in high demand as a female lead, often in a romantic capacity; she demonstrated a great versatility that made her equally at home in action (Dragon Heat, 2005) ,historical drama (Knot, 2006), and psychological thrillers (Diary, 2006). The actress made her Hollywood premiere with supporting billing in Rob Cohen's big-budget adventure sequel The Mummy: Tomb of the Dragon Emperor (2008).